Well there are many great quotes. Most of them coming from either Santana or Sue. I think I'll mention a few of Santana's best quotes because she just had so many:
“Admit it, Wonder Twins. The only reason why the New Directions beat the Troubletones at
Sectionals is because that pervy clown judge was freaking high as a kite.”
"Just because I hate everybody doesn't mean they have to hate me too."
"Well because I realized the world is even colder than I am. You know, and the only thing that can keep you from freezing to death is to have good friends around you to keep you warm."
"And just when you thought it couldn't get any gayer...it does"
"Kurt: Can we talk about the giant elephant in the room?
Santana: Your sexuality?"
"I just try to be really, really honest with people when I think that they suck! You know? No one gets it."
"Rumor has it that when I came out of my mother I told the nurse she was fat."
"Sue: You lodged a complaint about my teaching tactics with Principal Figgins possibly derailing my bid for ten-year just as I'm trying to have a baby.
Santana: A baby? With who's vagina?"