Probably a ~controversial~ pick but I'm not gonna go with any of the main series regions (although that would be Johto). I'm actually gonna go with the Orre region from Colosseum and XD Gale of Darkness. It may be from a spinoff but god damn I just love every single thing about this place! I've definitely had some of the most fun I've ever had in a Pokemon game in this region, there's a lot of unique stuff to do and places to explore and ofc the crackhead enemy teams are so much fun... Orre definitely does not get enough love nowadays honestly.