I think it's Janelle's iconic scene "RACHEL YOU'RE SO BEAUTIFUL JENN YOU'RE SUCH A BITCH" or whatever for the pure gay (lesbian) it awakened in my younger self
(aka the beau fight but the first part is ++++++++++)
also can we not forget that as annoying as ivette was that line was iconic "and they're pretty much telling the truth about each other but no drunk wants to hear the truth about themself"
dan's funeral/janelle's first hoh/keesha's birthday all were great
an underrated one that i loved was the one on bb13 where all the veteran alliance went out of the competition one by one (when brendon had just came back) until daniele won hoh LMAO such an iconic 10 mins
after revisiting it multiple times, I find the POV meeting in BB16 where Devin was HOH and Zach goes off on him to be one of the best moments in the entire show, and it indeed is a contender for the best episode of big brother